This paper presents a description of the new strategy for the fight against drugs implemented in Colombia since the year 2007. The Strategic Leap Forward, as the Colombian government has called the program, or the Strategic Development Initiative, as the United States Agency for International Development (USAID) calls it, is a step forward in the design of anti-drug policies that are more sustainable and effective in the mid-term. Currently, a pilot project is being implemented in the Macarena region, in the department of Meta (southeast of Bogotá), where coca crops and illicit activities were the norm just a few years ago. The Colombian State, partially financed by the United States governments and European countries, consolidates its presence in this region with the different instances and programs of the state apparatus to recover territorial control and combat the production of illicit drugs. But even more important is that this new approach in the fight against illegal drugs is based on a regional economic development plan, to avoid that peasants become involved in the first stages of cocaine production and trafficking process. The adequate functioning of this strategy can be a reference point to other countries that face similar problems of illicit drug production and conflict associated with these activities.